Green Ultrasound versus Conventional Synthesis and Characterization of Specific Task Pyridinium Ionic Liquid Hydrazones Tethering Fluorinated Counter Anions: Novel Inhibitors of Fungal Ergosterol Biosynthesis.

ABSTRACT: A series of specific task ionic liquids (ILs) based on a pyridiniumhydrazone scaffold in combination with hexafluorophosphate (PF₆^-), tetrafluoroboron (BF₄^-) and/or trifluoroacetate (CF₃COO^-) counter anion, were designed and characterized by IR, NMR and mass spectrometry. The reactions were conducted under both conventional and green ultrasound procedures. The antifungal potential of the synthesized compounds 2-25 was investigated against 40 strains of Candida (four standard and 36 clinical isolates). Minimum inhibitory concentrations (MIC₉₀) of the synthesized compounds were in the range of 62.5-2000 μg/mL for both standard and oral Candida isolates. MIC₉₀ results showed that the synthesized 1-(2-(4-chlorop

SUBMITTER: Rezki N 

PROVIDER: S-EPMC6150352 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature