Ontology highlight
ABSTRACT:
SUBMITTER: Lo SN
PROVIDER: S-EPMC6150360 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20171028 11
Berberine and the methylenedioxy ring-opening derivatives palmatine and jatrorrhizine are active ingredients in immunomodulatory plants, such as goldenseal. This study aimed to illustrate the effects of protoberberines on aryl hydrocarbon receptor (AhR) activation and cytochrome P450 (CYP) 1 in the estrogen receptor (ER)α(+) MCF-7 breast cancer cells. Among protoberberines at non-cytotoxic concentrations (≤10 μM), berberine had the most potent and statistically significant effects on AhR activat ...[more]