Glycemic Variation and Cardiovascular Risk in the Veterans Affairs Diabetes Trial.

ABSTRACT:

Objective

There is uncertainty about the importance of glycemic variability in cardiovascular complications in patients with type 2 diabetes. Using the Veterans Affairs Diabetes Trial (VADT), we investigated the association between variation in fasting glucose and glycated hemoglobin (HbA_1c) over time and the incidence of cardiovascular disease (CVD) and assessed whether this is influenced by intensive or standard glycemic control.

Research design and methods

During the VADT, fasting glucose and HbA_1c were measured every 3 months for up to 84 months in 1,791 individuals. Variability measures included coefficient of variation (CV) and average real variability (ARV) for fasting glucose and HbA_1c. Overall mean glucose and HbA_1c measur

SUBMITTER: Zhou JJ 

PROVIDER: S-EPMC6150432 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature