The genetics of retinopathy of prematurity: a model for neovascular retinal disease.

ABSTRACT:

Topic

Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease in premature infants, and is a major cause of childhood blindness worldwide. In addition to known clinical risk factors such as low birth weight and gestational age, there is a growing body of evidence supporting a genetic basis for ROP.

Clinical relevance

While comorbidities and environmental factors have been identified as contributing to ROP outcomes in premature infants, most notably gestational age and oxygen, some infants progress to severe disease despite absence of these clinical risk factors. The contribution of genetic factors may explain these differences and allow better detection and treatment of infants at risk for severe ROP.

Methods

To comprehensively review genetic fact

SUBMITTER: Swan R 

PROVIDER: S-EPMC6150458 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature