Calorie restriction does not influence oocyte quality in oocytes from POLG mitochondrial mutator mice.

ABSTRACT: It has recently been demonstrated that moderate adult onset caloric restriction (e.g. calorie restriction; CR) has a positive impact on female fertility in aged mice, due in large to preventing the age-associated decline in the quality of oocytes available for fertilization. The impact of CR on oocyte quality has been attributed, at least in part, to mitochondrial functions. In mitochondrial DNA (mtDNA) mutator mice (PolgD257A/D257A), which harbor a mutation in the proofreading mtDNA polymerase-gamma (POLG), mitochondrial mutations rapidly accumulate, resulting in a premature aging phenotype and female infertility. As CR has been shown to extend both lifespan and 'healthspan' as well as improve oocyte quality in aged mice, we investigated whether adult onset CR could improve oocyte quality

SUBMITTER: Faraci C 

PROVIDER: S-EPMC6150528 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature