Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity.

ABSTRACT: In the auditory system, type I spiral ganglion neurons (SGNs) convey complex acoustic information from inner hair cells (IHCs) to the brainstem. Although SGNs exhibit variation in physiological and anatomical properties, it is unclear which features are endogenous and which reflect input from synaptic partners. Using single-cell RNA sequencing, we derived a molecular classification of mouse type I SGNs comprising three subtypes that express unique combinations of Ca²⁺ binding proteins, ion channel regulators, guidance molecules, and transcription factors. Based on connectivity and susceptibility to age-related loss, these subtypes correspond to those defined physiologically. Additional intrinsic differences among subtypes and across the tonotopic axis highlight an unexpectedly a

SUBMITTER: Shrestha BR 

PROVIDER: S-EPMC6150604 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature