Nonlinear Photoacoustic Imaging by in situ Multiphoton Upconversion and Energy Transfer.

ABSTRACT: In recent years, photoacoustic tomography (PAT) is increasingly used in biomedical research, as it allows for direct visualization of optical absorption in deep tissue. In addition to vascular and hemodynamic imaging using endogenous contrasts, PAT is also capable of imaging neural and molecular dynamics with extrinsic contrasts. While near-infrared (NIR)-absorbing contrasts are preferred for deep tissue imaging, compared to visible-light-absorbing contrasts, they are much harder to design and synthesize with good environmental stability. We introduce here a new PAT mode which utilizes nonlinear multiphoton upconversion of NIR light in situ to visible light, thus exciting locally a dye that can generate strong photoacoustic signal. This approach allows to take advantage of a large l

SUBMITTER: Wang D 

PROVIDER: S-EPMC6150608 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature