Predictors of Rapid Aortic Root Dilation and Referral for Aortic Surgery in Marfan Syndrome.

ABSTRACT: Few data exist regarding predictors of rapid aortic root dilation and referral for aortic surgery in Marfan syndrome (MFS). To identify independent predictors of the rate of aortic root (AoR) dilation and referral for aortic surgery, we investigated the data from the Pediatric Heart Network randomized trial of atenolol versus losartan in young patients with MFS. Data were analyzed from the echocardiograms at 0, 12, 24, and 36 months read in the core laboratory of 608 trial subjects, aged 6 months to 25 years, who met original Ghent criteria and had an AoR z-score (AoRz) > 3. Repeated measures linear and logistic regressions were used to determine multivariable predictors of AoR dilation. Receiver operator characteristic curves were used to determine cut-points in AoR dilation predicting re

SUBMITTER: Hoskoppal A 

PROVIDER: S-EPMC6150800 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature