Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network.

ABSTRACT: Cells utilize dynamic, network-level rearrangements in highly interconnected protein interaction networks to transmit and integrate information from distinct signaling inputs. Despite the importance of protein interaction network dynamics, the organizational logic underlying information flow through these networks is not well understood. Previously, we developed the quantitative multiplex co-immunoprecipitation platform, which allows for the simultaneous and quantitative measurement of the amount of co-association between large numbers of proteins in shared complexes. Here, we adapt quantitative multiplex co-immunoprecipitation to define the activity-dependent dynamics of an 18-member protein interaction network in order to better understand the underlying principles governing glutamatergi

SUBMITTER: Lautz JD 

PROVIDER: S-EPMC6150823 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature