An ensemble of mathematical models showing diauxic growth behaviour.

ABSTRACT:

Background

Carbon catabolite repression (CCR) controls the order in which different carbon sources are metabolised. Although this system is one of the paradigms of regulation in bacteria, the underlying mechanisms remain controversial. CCR involves the coordination of different subsystems of the cell - responsible for the uptake of carbon sources, their breakdown for the production of energy and precursors, and the conversion of the latter to biomass. The complexity of this integrated system, with regulatory mechanisms cutting across metabolism, gene expression, and signalling, has motivated important modelling efforts over the past four decades, especially in the enterobacterium Escherichia coli.

Results

Starting from a simple core model with only four intracellular metabol

SUBMITTER: Kremling A 

PROVIDER: S-EPMC6151013 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature