Transcriptional profiling of liver during the critical embryo-to-hatchling transition period in the chicken (Gallus gallus).

ABSTRACT:

Background

Although hatching is perhaps the most abrupt and profound metabolic challenge that a chicken must undergo; there have been no attempts to functionally map the metabolic pathways induced in liver during the embryo-to-hatchling transition. Furthermore, we know very little about the metabolic and regulatory factors that regulate lipid metabolism in late embryos or newly-hatched chicks. In the present study, we examined hepatic transcriptomes of 12 embryos and 12 hatchling chicks during the peri-hatch period-or the metabolic switch from chorioallantoic to pulmonary respiration.

Results

Initial hierarchical clustering revealed two distinct, albeit opposing, patterns of hepatic gene expression. Cluster A genes are largely lipolytic and highly expressed in embryos. While

SUBMITTER: Cogburn LA 

PROVIDER: S-EPMC6151027 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature