Required growth facilitators propel axon regeneration across complete spinal cord injury.

ABSTRACT: Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury^1-3, but efficient reversal of this regrowth failure remains elusive⁴. Here we show that three factors that are essential for axon growth during development but are attenuated or lacking in adults-(i) neuron intrinsic growth capacity^2,5-9, (ii) growth-supportive substrate^10,11 and (iii) chemoattraction^12,13-are all individually required and, in combination, are sufficient to stimulate robust axon regrowth across anatomically complete SCI lesions in adult rodents. We reactivated the growth capacity of mature descending propriospinal neuron

SUBMITTER: Anderson MA 

PROVIDER: S-EPMC6151128 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature