Short-term costs of integrating whole-genome sequencing into primary care and cardiology settings: a pilot randomized trial.

ABSTRACT:

Purpose

Great uncertainty exists about the costs associated with whole-genome sequencing (WGS).

Methods

One hundred cardiology patients with cardiomyopathy diagnoses and 100 ostensibly healthy primary care patients were randomized to receive a family-history report alone or with a WGS report. Cardiology patients also reviewed prior genetic test results. WGS costs were estimated by tracking resource use and staff time. Downstream costs were estimated by identifying services in administrative data, medical records, and patient surveys for 6 months.

Results

The incremental cost per patient of WGS testing was $5,098 in cardiology settings and $5,073 in primary care settings compared with family history alone. Mean 6-month downstream costs did not differ statistically betw

SUBMITTER: Christensen KD 

PROVIDER: S-EPMC6151171 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature