Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression.

ABSTRACT:

Background

The neurobiological mechanisms involved in divergent appetitive phenotypes in major depressive disorder (MDD) are not well understood, although recent data suggest disruption in mesolimbic reward circuitry. Ghrelin, an orexigenic hormone, has been shown to modulate the reward circuitry. We aimed to investigate the relationship between acylated ghrelin levels and the neural response to food stimuli in individuals with hyperphagic and hypophagic MDD in remission.

Methods

Women with hyperphagic MDD (n = 10), hypophagic MDD (n = 18), and healthy controls (HC; n = 18) underwent fMRI scanning during which they viewed images of food. The fMRI session was followed by a standardized meal, appetite ratings, and serial blood draws.

Results

In individuals with hyperpha

SUBMITTER: Cerit H 

PROVIDER: S-EPMC6151278 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature