Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels by β-blocker carvedilol.

ABSTRACT:

Background and purpose

Carvedilol is a clinically effective β-blocker broadly used for treating congestive heart failure (CHF), and several clinical trials have demonstrated that it shows a favourable effect compared with other β-blockers in patients with CHF. The mechanism underlying this beneficial effect of carvedilol compared to other β-blockers is not clearly understood. In addition to β-blockers, inhibitors of hyperpolarization-activated cyclic nucleotide (HCN)-gated channels, which play a critical role in spontaneous rhythmic activity in the heart, have also been proposed to be suitable drugs for reducing heart rate and, therefore, beneficial for treating CHF. In the present study, we investigated the effect of carvedilol on HCN channels.

Experimental approach

Whole-c

SUBMITTER: Cao Y 

PROVIDER: S-EPMC6151329 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature