DS-70, a novel and potent α₄ integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs.

ABSTRACT:

Background and purpose

Allergic conjunctivitis is an eye inflammation that involves the infiltration of immune cells into the conjunctiva via cell surface-adhesion receptors, such as integrin α₄ β₁ . These receptors interact with adhesion molecules expressed on the conjunctival endothelium and may be a target to treat this disease. We synthesized DS-70, a novel α/β-peptidomimetic α₄ integrin antagonist, to prevent the conjunctival infiltration of immune cells and clinical symptoms in a model of allergic conjunctivitis.

Experimental approach

In vitro, DS-70 was pharmacologically characterized using a scintillation proximity procedure to measure its affinity for α₄ β₁ integrin, and its effect on cell adhesion mediated by d

SUBMITTER: Dattoli SD 

PROVIDER: S-EPMC6151342 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature