Skin Penetration Enhancement by Natural Oils for Dihydroquercetin Delivery.

ABSTRACT: Natural oils are commonly used in topical pharmaceutical formulations as emulsifiers, stabilizers or solubility enhancers. They are presented as safe and inert components, mainly used for formulation purposes. It is confirmed that natural oils can affect the skin penetration of various substances. Fatty acids are mainly responsible for this effect. Current understanding lacks reliable scientific data on penetration of natural oils into the skin and their skin penetration enhancement potential. In the current study, fatty acid content analysis was used to determine the principal fatty acids in soybean, olive, avocado, sea-buckthorn pulp, raspberry seed and coconut oils. Time of flight secondary ion mass spectrometry bioimaging was used to determine the distribution of these fatty acids in h

SUBMITTER: Cizinauskas V 

PROVIDER: S-EPMC6151382 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature