Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones.

ABSTRACT: Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values of 77.9 to 312 µM against Staphylococcus aureus, Streptococcus mutans, and Streptococcus sanguinis. Compounds 2, 7, 10, and 18 presented potent effects against Mycobacterium tuberculosis (57.2 µM ≤ MIC ≤ 70.9 µM). Hydrophilic effects caused by substituents on ring B increased antibacterial activity against Gram-positive species. Thus, log P_o/w were calculated by using high-performance li

SUBMITTER: Polaquini CR 

PROVIDER: S-EPMC6151560 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature