Furanones and Anthranilic Acid Derivatives from the Endophytic Fungus Dendrothyrium variisporum.

ABSTRACT: Extracts from an endophytic fungus isolated from the roots of the Algerian plant Globularia alypum showed prominent antimicrobial activity in a screening for novel antibiotics. The producer organism was identified as Dendrothyrium variisporum by means of morphological studies and molecular phylogenetic methods. Studies on the secondary metabolite production of this strain in various culture media revealed that the major components from shake flasks were massarilactones D (1) and H (2) as well as two new furanone derivatives for which we propose the trivial names (5S)-cis-gregatin B (3) and graminin D (4). Scale-up of the fermentation in a 10 L bioreactor yielded massarilactone D and several further metabolites. Among those were three

SUBMITTER: Teponno RB 

PROVIDER: S-EPMC6151570 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature