Coordinate systems for supergenomes.

ABSTRACT:

Background

Genome sequences and genome annotation data have become available at ever increasing rates in response to the rapid progress in sequencing technologies. As a consequence the demand for methods supporting comparative, evolutionary analysis is also growing. In particular, efficient tools to visualize-omics data simultaneously for multiple species are sorely lacking. A first and crucial step in this direction is the construction of a common coordinate system. Since genomes not only differ by rearrangements but also by large insertions, deletions, and duplications, the use of a single reference genome is insufficient, in particular when the number of species becomes large.

Results

The computational problem then becomes to determine an order and orientations of optimal

SUBMITTER: Gartner F 

PROVIDER: S-EPMC6151955 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature