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Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum.


ABSTRACT: Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh?(OCOCF?)?] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.

SUBMITTER: Lin J 

PROVIDER: S-EPMC6152040 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum.

Lin Jie J   Niu Shubin S   Ding Zhengfeng Z   Wang Renlei R   Dai Qun Q   Wei Wei W   Luo Rongrong R   Liu Ling L  

Molecules (Basel, Switzerland) 20170712 7


Inflatin G (<b>1</b>), a new aphidicolin analogue, together with seven known compounds inflatin A (<b>2</b>), inflatin B (<b>3</b>), aphidicolin (<b>4</b>), aphidicolin-17-monoacetate (<b>5</b>), gulypyrone A (<b>6</b>), pyridoxatin rotamers A (<b>7</b>) and B (<b>8</b>), were isolated from the ascomycete fungus <i>Tolypocladium inflatum</i>. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh₂(OCOCF₃)₄] complexes. Compounds <b>1</b>, <  ...[more]

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