Multifunctional Cinnamic Acid Derivatives.

ABSTRACT: Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino) ethan-1-ol. The synthesized molecules were evaluated as trypsin, lipoxygenase and lipid peroxidation inhibitors and for their cytotoxicity. Compound 2b derived from phenoxyphenyl cinnamic acid and propranolol showed the highest lipoxygenase (LOX) inhibition (IC₅₀ = 6 μΜ) and antiproteolytic activity (IC₅₀ = 0.425 μΜ). The conjugate 1a of simple cinnamic acid with propranolol showed the higher antiproteolytic activity (IC₅₀ = 0.315 μΜ) and good LOX inhibitory activity (IC₅₀ = 66 μΜ). Compounds 3a and 3b, derived from methoxylated

SUBMITTER: Peperidou A 

PROVIDER: S-EPMC6152057 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature