Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.

ABSTRACT: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease worldwide, but its molecular pathogenesis is not well defined, and there are no specific treatments. In humans, there is a strong genetic component determining susceptibility to DN. However, specific genes controlling DN susceptibility in humans have not been identified. In this study, we describe a mouse model combining type 1 diabetes with activation of the renin-angiotensin system (RAS), which develops robust kidney disease with features resembling human DN: heavy albuminuria, hypertension, and glomerulosclerosis. Additionally, there is a powerful effect of genetic background regulating susceptibility to nephropathy; the 129 strain is susceptible to kidney disease, whereas the C57BL/6 strain is resistant. To examine

SUBMITTER: Gurley SB 

PROVIDER: S-EPMC6152345 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature