The role of inter-species interactions in Salinispora specialized metabolism.

ABSTRACT: Bacterial genome sequences consistently contain many more biosynthetic gene clusters encoding specialized metabolites than predicted by the compounds discovered from the respective strains. One hypothesis invoked to explain the cryptic nature of these gene clusters is that standard laboratory conditions do not provide the environmental cues needed to trigger gene expression. A potential source of such cues is other members of the bacterial community, which are logical targets for competitive interactions. In this study, we examined the effects of such interactions on specialized metabolism in the marine actinomycete Salinispora tropica. The results show that antibiotic activities and the concentration of some small molecules increase in the presence of co-occurring bacterial strains relati

SUBMITTER: Patin NV 

PROVIDER: S-EPMC6152374 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature