Unfavorable and favorable changes in modifiable risk factors and incidence of coronary heart disease: The Whitehall II cohort study.

ABSTRACT:

Background

Few studies have examined long-term associations of unfavorable and favorable changes in vascular risk factors with incident coronary heart disease (CHD). We examined this issue in a middle-aged disease-free population.

Methods

We used repeat data from the Whitehall II cohort study. Five biomedical, behavioral and psychosocial examinations of 8335 participants without CHD produced up to 20,357 person-observations to mimic a non-randomized pseudo-trial. After measurement of potential change in 6 risk factors twice (total cholesterol, blood pressure, smoking, overweight, psychological distress, problems in social relationships), a 5-year follow-up of CHD was undertaken.

Results

Incidence of CHD was 7.4/1000 person-years. Increases from normal to high choleste

SUBMITTER: Virtanen M 

PROVIDER: S-EPMC6152587 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature