The Human Brain Traverses a Common Activation-Pattern State Space Across Task and Rest.

ABSTRACT: Much of our lives are spent in unconstrained rest states, yet cognitive brain processes are primarily investigated using task-constrained states. It may be possible to utilize the insights gained from experimental control of task processes as reference points for investigating unconstrained rest. To facilitate comparison of rest and task functional magnetic resonance imaging data, we focused on activation amplitude patterns, commonly used for task but not rest analyses. During rest, we identified spontaneous changes in temporally extended whole-brain activation-pattern states. This revealed a hierarchical organization of rest states. The top consisted of two competing states consistent with previously identified "task-positive" and "task-negative" activation patterns. These states were com

SUBMITTER: Chen RH 

PROVIDER: S-EPMC6152856 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature