Evaluation of antigen-specific immune responses for leprosy diagnosis in a hyperendemic area in China.

ABSTRACT:

Objective

To evaluate antigen-specific immune responses for leprosy diagnosis in a hyperendemic area in China.

Methods

Eighty-three leprosy patients and 161 non-leprosy controls were enrolled from Hani-yi Autonomous Prefecture of Honghe, Yunnan Province, China. Leprosy patients were divided into multibacillary (MB, n = 38), paucibacillary (PB, n = 23), and post-multi-drug therapy (MDT, n = 22) groups. Controls were divided into the following groups: healthy household contacts (HHC, n = 119), tuberculosis (TB, n = 11), and endemic controls (EC, n = 31). The NDO-LID Rapid Test, M. leprae antigen-specific ELISA and antigen-specific IFN-γ secretion in a whole blood assay (WBA) were used to evaluate these subjects.

Results

The NDO-LID Rapid Test achieved higher positive re

SUBMITTER: Chen X 

PROVIDER: S-EPMC6152862 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature