Functionalized Cyclopentanes via Sc(III)-Catalyzed Intramolecular Enolate Alkylation.

ABSTRACT: We report herein the intramolecular α-tert-alkylation of unsaturated β-ketoesters which gives rise to highly functionalized cyclopentanes. This strategy is characterized by its operational simplicity, mild reaction conditions and the use of scandium(III) triflate as a Lewis acid catalyst. Of interest, cyclopentanes bearing heterocycles, sites for post reaction functionalization and spirocyclic architectures are accessible with this strategy.

SUBMITTER: McAtee CC 

PROVIDER: S-EPMC6152925 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature