GDF-15, Galectin 3, Soluble ST2, and Risk of Mortality and Cardiovascular Events in CKD.

ABSTRACT:

Rationale & objective

Inflammation, cardiac remodeling, and fibrosis may explain in part the excess risk for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). Growth differentiation factor 15 (GDF-15), galectin 3 (Gal-3), and soluble ST2 (sST2) are possible biomarkers of these pathways in patients with CKD.

Study design

Observational cohort study.

Setting & participants

Individuals with CKD enrolled in either of 2 multicenter CKD cohort studies: the Seattle Kidney Study or C-PROBE (Clinical Phenotyping and Resource Biobank Study).

Exposures

Circulating GDF-15, Gal-3, and sST2 measured at baseline.

Outcomes

Primary outcome was all-cause mortality. Secondary outcomes included hospitalization for physician-adjudicated heart failure

SUBMITTER: Tuegel C 

PROVIDER: S-EPMC6153047 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature