Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype.

ABSTRACT: Patients with atopic dermatitis (AD) are commonly colonized with Staphylococcus aureus (AD S. aureus⁺), but what differentiates this group from noncolonized AD patients (AD S. aureus^-) has not been well studied. To evaluate whether these two groups have unique phenotypic or endotypic features, we performed a multicenter, cross-sectional study enrolling AD S. aureus⁺ (n = 51) and AD S. aureus^- (n = 45) participants defined by the presence or absence of S. aureus by routine culture techniques and nonatopic, noncolonized control individuals (NA S. aureus^-) (n = 46). Filaggrin (FLG) genotypes were determined, and disease severity (Eczema Area and Severity Index, Rajka-Langeland Severity Score, Investigator's Global Assessment score, Numeri

SUBMITTER: Simpson EL 

PROVIDER: S-EPMC6153055 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature