Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer's disease.

ABSTRACT:

Objective

Previous studies suggest that the brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism may influence symptom onset in Alzheimer's disease (AD). Our recent cross-sectional findings suggest that Met66 may influence clinical expression in dominantly inherited AD (DIAD) through its effects on tau. However, it remains unclear whether carriage of Met66 in DIAD results in faster increases in cerebrospinal fluid (CSF) tau and ptau₁₈₁ , and whether these increases are associated with accelerated brain volume loss and memory decline.

Methods

A total of 211 subjects (101 mutation noncarriers, 110 mutation carriers), who were cognitively normal, as defined by a Clinical Dementia Rating global score of 0, completed assessments of cognitive function

SUBMITTER: Lim YY 

PROVIDER: S-EPMC6153076 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature