Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice.

ABSTRACT: Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during sepsis. TDCA increases the number of granulocytic myeloid-derived suppressor cells (MDSC_LT) distinctive from MDSCs obtained without TDCA treatment (MDSC_L) in the spleen of septic mice. FACS-sorted MDSC_LT cells suppress T-cell proliferation and confer protection against sepsis when adoptively transferred better than MDSC_L. Proteogenomic analysis indicated that TDCA controls chromatin silencing, alternative splicing, and translation of the immune proteome of

SUBMITTER: Chang S 

PROVIDER: S-EPMC6153344 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature