Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial.

ABSTRACT:

Introduction

Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown.

Methods

Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment.

Results

tDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. D

SUBMITTER: Tsapkini K 

PROVIDER: S-EPMC6153381 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature