Heparin: role in protein purification and substitution with animal-component free material.

ABSTRACT: Heparin is a highly sulfated polysaccharide which belongs to the family of glycosaminoglycans. It is involved in various important biological activities. The major biological purpose is the inhibition of the coagulation cascade to maintain the blood flow in the vasculature. These properties are employed in several therapeutic drugs. Heparin's activities are associated with its interaction to various proteins. To date, the structural heparin-protein interactions are not completely understood. This review gives a general overview of specific patterns and functional groups which are involved in the heparin-protein binding. An understanding of the heparin-protein interactions at the molecular level is not only advantageous in the therapeutic application but also in biotechnological application

SUBMITTER: Bolten SN 

PROVIDER: S-EPMC6153649 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature