High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

ABSTRACT: The bacterial cell wall maintains cell shape and protects against bursting by turgor. A major constituent of the cell wall is peptidoglycan (PG), which is continuously modified to enable cell growth and differentiation through the concerted activity of biosynthetic and hydrolytic enzymes. Streptomycetes are Gram-positive bacteria with a complex multicellular life style alternating between mycelial growth and the formation of reproductive spores. This involves cell wall remodeling at apical sites of the hyphae during cell elongation and autolytic degradation of the vegetative mycelium during the onset of development and antibiotic production. Here, we show that there are distinct differences in the cross-linking and maturation of the PGs between exponentially growing vegetative hyphae and t

SUBMITTER: van der Aart LT 

PROVIDER: S-EPMC6153666 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature