A Novel Bvg-Repressed Promoter Causes vrg-Like Transcription of fim3 but Does Not Result in the Production of Serotype 3 Fimbriae in Bvg^- Mode Bordetella pertussis.

ABSTRACT: In Bordetella pertussis, two serologically distinct fimbriae, FIM2 and FIM3, undergo on/off phase variation independently of each other via variation in the lengths of C stretches in the promoters for their major subunit genes, fim2 and fim3 These two promoters are also part of the BvgAS virulence regulon and therefore, if in an on configuration, are activated by phosporylated BvgA (BvgA~P) under normal growth conditions (Bvg⁺ mode) but not in the Bvg^- mode, inducible by growth in medium containing MgSO₄ or other compounds, termed modulators. In the B. pertussis Tohama I strain (FIM2⁺ FIM3^-), the fim3 promoter is in the off state. However, a high level of transcription of the fim3 gene is obser

SUBMITTER: Chen Q 

PROVIDER: S-EPMC6153668 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature