Ontology highlight
ABSTRACT:
SUBMITTER: Dabos L
PROVIDER: S-EPMC6153822 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20180924 10
OXA-535 is a chromosome-encoded carbapenemase of <i>Shewanella bicestrii</i> JAB-1 that shares only 91.3% amino acid sequence identity with OXA-48. Catalytic efficiencies are similar to those of OXA-48 for most β-lactams, except for ertapenem, where a 2,000-fold-higher efficiency was observed with OXA-535. OXA-535 and OXA-436, a plasmid-encoded variant of OXA-535 differing by three amino acids, form a novel cluster of distantly related OXA-48-like carbapenemases. Comparison of <i>bla</i><sub>OXA ...[more]