Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection.

ABSTRACT: Antibiotic disruption of the intestinal microbiota favors colonization by Clostridium difficile Using a charcoal-based adsorbent to decrease intestinal antibiotic concentrations, we studied the relationship between antibiotic concentrations in feces and the intensity of dysbiosis and quantified the link between this intensity and mortality. We administered either moxifloxacin (n = 70) or clindamycin (n = 60) to hamsters by subcutaneous injection from day 1 (D₁) to D₅ and challenged them with a C. difficile toxigenic strain at D₃ Hamsters received various doses of a charcoal-based adsorbent, DAV131A, to modulate intestinal antibiotic concentrations. Gut dysbiosis was evaluated at D₀ and D₃ using diversity ind

SUBMITTER: Burdet C 

PROVIDER: S-EPMC6153837 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature