Systematic miRNome profiling reveals differential microRNAs in transgenic maize metabolism.

ABSTRACT:

Background

While some genetically modified organisms (GMOs) are created to produce new double-stranded RNA molecules (dsRNA), in others, such molecules may occur as an unintended effect of the genetic engineering process. Furthermore, GMOs might produce naturally occurring dsRNA molecules in higher or lower quantities than its non-transgenic counterpart. This study is the first to use high-throughput technology to characterize the miRNome of commercialized GM maize events and to investigate potential alterations in miRNA regulatory networks.

Results

Thirteen different conserved miRNAs were found to be dys-regulated in GM samples. The insecticide Bt GM variety had the most distinct miRNome. These miRNAs target a range of endogenous transcripts, such as transcription factors a

SUBMITTER: Agapito-Tenfen SZ 

PROVIDER: S-EPMC6153861 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature