Partial volume correction for improved PET quantification in ¹⁸F-NaF imaging of atherosclerotic plaques.

ABSTRACT:

Background

Accurate quantification of plaque imaging using ¹⁸F-NaF PET requires partial volume correction (PVC).

Methods

PVC of PET data was implemented by the use of a local projection (LP) method. LP-based PVC was evaluated with an image quality (NEMA) and with a thorax phantom with "plaque-type" lesions of 18-36 mL. The validated PVC method was then applied to a cohort of 17 patients, each with at least one plaque in the carotid or ascending aortic arteries. In total, 51 calcified (HU > 110) and 16 non-calcified plaque lesions (HU < 110) were analyzed. The lesion-to-background ratio (LBR) and the relative change of LBR (ΔLBR) were measured on PET.

Results

Following PVC, LBR of the spheres (NEMA phantom) was within 10% of the original values. LBR of the t

SUBMITTER: Cal-Gonzalez J 

PROVIDER: S-EPMC6153866 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature