C-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells.

ABSTRACT: Abstract: GNA12 is the α subunit of a heterotrimeric G protein that possesses oncogenic potential. Activated GNA12 also promotes prostate and breast cancer cell invasion in vitro and in vivo, and its expression is up-regulated in many tumors, particularly metastatic tissues. In this study, we explored the control of expression of GNA12 in prostate cancer cells. Initial studies on LnCAP (low metastatic potential, containing low levels of GNA12) and PC3 (high metastatic potential, containing high GNA12 levels) cells revealed that GNA12 mRNA levels correlated with protein levels, suggesting control at the transcriptional level. To identify potential factors controlling GNA12 transcription, we cloned the upstream 5' regulatory region of the human GNA12 gene and examined it

SUBMITTER: Udayappan UK 

PROVIDER: S-EPMC6153990 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature