Immune stimuli shape the small non-coding transcriptome of extracellular vesicles released by dendritic cells.

ABSTRACT: The release and uptake of nano-sized extracellular vesicles (EV) is a highly conserved means of intercellular communication. The molecular composition of EV, and thereby their signaling function to target cells, is regulated by cellular activation and differentiation stimuli. EV are regarded as snapshots of cells and are, therefore, in the limelight as biomarkers for disease. Although research on EV-associated RNA has predominantly focused on microRNAs, the transcriptome of EV consists of multiple classes of small non-coding RNAs with potential gene-regulatory functions. It is not known whether environmental cues imposed on cells induce specific changes in a broad range of EV-associated RNA classes. Here, we investigated whether immune-activating or -suppressing stimuli imposed on primary

SUBMITTER: Driedonks TAP 

PROVIDER: S-EPMC6154026 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature