Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China.

ABSTRACT: The substantial increase in prevalence and emergence of antigenically divergent or highly pathogenic influenza A(H7N9) viruses during 2016-17 raises concerns about the epizootic potential of these viruses. We investigated the evolution and adaptation of H7N9 viruses by analyzing available data and newly generated virus sequences isolated in Guangdong Province, China, during 2015-2017. Phylogenetic analyses showed that circulating H7N9 viruses belong to distinct lineages with differing spatial distributions. Hemagglutination inhibition assays performed on serum samples from patients infected with these viruses identified 3 antigenic clusters for 16 strains of different virus lineages. We used ancestral sequence reconstruction to identify parallel amino acid changes on multiple separate line

SUBMITTER: Lu J 

PROVIDER: S-EPMC6154164 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature