Evaluation of the Mycobactericidal Effect of Thio-functionalized Carbohydrate Derivatives.

ABSTRACT: Sugars with heteroatoms other than oxygen have attained considerable importance in glycobiology and in drug design since they are often more stable in blood plasma due to their resistance to enzymes, such as glycosidases, phosphorylases and glycosyltransferases. The replacement of oxygen atoms in sugars with sulfur forms thio-sugars, which are potentially useful for the treatment of diabetes and some bacterial and viral infections. Here, we evaluated the antibacterial activity of thio-functionalized carbohydrate derivatives. A set of 21 compounds was screened against acid-fast Mycobacterium tuberculosis (Mtb), gram-negative Escherichia coli and gram-positive Staphylococcus aureus. The tested carbohydrate derivatives were most effective against tubercle bacilli,

SUBMITTER: Korycka-Machala M 

PROVIDER: S-EPMC6154314 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature