Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.

ABSTRACT: Insight into the mechanisms of intestinal transport and metabolism of aspalathin will provide important information for dose optimisation, in particular for studies using mouse models. Aspalathin transportation across the intestinal barrier (Caco-2 monolayer) tested at 1-150 µM had an apparent rate of permeability (P_app) typical of poorly absorbed compounds (1.73 × 10^-6 cm/s). Major glucose transporters, sodium glucose linked transporter 1 (SGLT1) and glucose transporter 2 (GLUT2), and efflux protein (P-glycoprotein, PgP) (1.84 × 10^-6 cm/s; efflux ratio: 1.1) were excluded as primary transporters, since the P_app of aspalathin was not affected by the presence of specific inhibitors. The P_app of aspalathin was also not affected by consti

SUBMITTER: Bowles S 

PROVIDER: S-EPMC6154319 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature