Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort.

ABSTRACT:

Background

Anticholinergic medication exposure has been associated with increased risk for dementia. No study has examined the association between anticholinergic medication use and neuropathologic lesions in a community-based sample.

Objective

To examine the relationship between anticholinergic exposure and dementia-related neuropathologic changes.

Methods

Within a community-based autopsy cohort (N = 420), we ascertained use of anticholinergic medications over a 10-year period from automated pharmacy data and calculated total standardized daily doses (TSDD). We used modified Poisson regression to calculate adjusted relative risks (RRs) and 95% confidence intervals (CIs) for the association between anticholinergic exposure and dementia-associated neuropathology. Inver

SUBMITTER: Gray SL 

PROVIDER: S-EPMC6154381 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature