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Design, synthesis, biological evaluation and molecular docking studies of novel 3-substituted-5-[(indol-3-yl)methylene]-thiazolidine-2,4-dione derivatives.

ABSTRACT: Various thiazolidine-2,4-dione derivatives 3a-l possessing indole moiety were designed, synthesized using appropriate conventional heating as well as microwave irradiation methods. All the synthesized compounds were characterized physically and spectrally. The compounds were evaluated for in vitro antibacterial activity, in vitro antioxidant activity and in vivo hypoglycemic activity in relation to the standard drugs. Most of the new compounds exhibited moderate activity and some showed considerable activity. Molecular docking studies were carried out using AutoDock software and revealed that compound 3b has significant binding interaction with PPAR? receptor compared with the standard ligand Rosiglitazone.

SUBMITTER: Srikanth Kumar K 

PROVIDER: S-EPMC6154471 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Design, synthesis, biological evaluation and molecular docking studies of novel 3-substituted-5-[(indol-3-yl)methylene]-thiazolidine-2,4-dione derivatives.

Srikanth Kumar K K   Lakshmana Rao A A   Basaveswara Rao M V MV  

Heliyon 20180920 9

Various thiazolidine-2,4-dione derivatives <b>3a-l</b> possessing indole moiety were designed, synthesized using appropriate conventional heating as well as microwave irradiation methods. All the synthesized compounds were characterized physically and spectrally. The compounds were evaluated for <i>in vitro</i> antibacterial activity, <i>in vitro</i> antioxidant activity and <i>in vivo</i> hypoglycemic activity in relation to the standard drugs. Most of the new compounds exhibited moderate activ  ...[more]

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