Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis.

ABSTRACT: Two new compounds isobenzofuranone A (1) and indandione B (2), together with eleven known compounds (3-13) were isolated from liquid cultures of an endophytic fungus Alternaria sp., which was obtained from the medicinal plant Morinda officinalis. Among them, the indandione (2) showed a rarely occurring indanone skeleton in natural products. Their structures were elucidated mainly on the basis of extensive spectroscopic data analysis. All of the compounds were evaluated with cytotoxic and α-glucosidase inhibitory activity assays. Compounds 11 and 12 showed significant inhibitory activities against four tumor cell lines; MCF-7, HepG-2, NCI-H460 and SF-268, with IC₅₀ values in the range of 1.91-9.67 μM, and compounds

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6154570 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature