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Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis.

ABSTRACT: Two new compounds isobenzofuranone A (1) and indandione B (2), together with eleven known compounds (3-13) were isolated from liquid cultures of an endophytic fungus Alternaria sp., which was obtained from the medicinal plant Morinda officinalis. Among them, the indandione (2) showed a rarely occurring indanone skeleton in natural products. Their structures were elucidated mainly on the basis of extensive spectroscopic data analysis. All of the compounds were evaluated with cytotoxic and ?-glucosidase inhibitory activity assays. Compounds 11 and 12 showed significant inhibitory activities against four tumor cell lines; MCF-7, HepG-2, NCI-H460 and SF-268, with IC50 values in the range of 1.91-9.67 ?M, and compounds 4, 5, 9, 10, 12 and 13 showed excellent inhibitory activities against ?-glucosidase with IC50 values in the range of 12.05-166.13 ?M.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6154570 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis.

Wang Ying Y   Liu Hong-Xin HX   Chen Yu-Chan YC   Sun Zhang-Hua ZH   Li Hao-Hua HH   Li Sai-Ni SN   Yan Ming-Li ML   Zhang Wei-Min WM  

Molecules (Basel, Switzerland) 20170508 5

Two new compounds isobenzofuranone A (<b>1</b>) and indandione B (<b>2</b>), together with eleven known compounds (<b>3</b>-<b>13</b>) were isolated from liquid cultures of an endophytic fungus <i>Alternaria</i> sp., which was obtained from the medicinal plant <i>Morinda officinalis</i>. Among them, the indandione (<b>2</b>) showed a rarely occurring indanone skeleton in natural products. Their structures were elucidated mainly on the basis of extensive spectroscopic data analysis. All of the co  ...[more]

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