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New Glycosides from the Fruits of Nicandra physaloides.

ABSTRACT: Three new glycosides (1-3) and 15 known ones (4-18) were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (4-18) were the first time isolated from the Nicandra genus and they (except 8, 10, 14) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC50 values from 26.9 to 47.5 ?M.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6154662 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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New Glycosides from the Fruits of Nicandra physaloides.

Liu Yan Y   Jiang Hai-Bing HB   Xu Zhen-Peng ZP   Cheng Yan-Gang YG   Lv Shao-Wa SW   Yang Bing-You BY   Guo Hong-Wei HW   Kuang Hai-Xue HX  

Molecules (Basel, Switzerland) 20170517 5

Three new glycosides (<b>1</b>-<b>3</b>) and 15 known ones (<b>4</b>-<b>18</b>) were isolated and identified from the fruits of <i>Nicandra physaloides</i>. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (<b>4</b>-<b>18</b>) were the first time isolated from the <i>Nicandra</i> genus and they (except <b>8</b>, <b>10</b>, <b>14</b>) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC<sub>50</sub> values from 26.9  ...[more]

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