Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes.

ABSTRACT: The quest for alternative drugs with respect to the well-known cis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes,

SUBMITTER: Caporale A 

PROVIDER: S-EPMC6154682 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature